I want to understand the section, "What do extra TP53 genes cost?" in this paper: [login to view URL]
If you can help me understand it, I am willing to pay. Things you’ll need to know are: what “overexpress Trp53” means, what “increases in TP53 copy number” means and how it is achieved, what an “inducible promoter” is, what a “p44 isoform” is, what the difference is between super p53 mice and the other overexpressing trp53 mice, how mdm2 relates, what regulation of tp53 transcription is, what negative post-transcriptional regulation” is, what “trp-53 dependent embryonic lethality” is, what TP53RTG genes are, and how all these data indicate that increased TP53 dosage comes with a cost, and suggest that Proboscideans evolved a mechanism that reduced this cost, broke a major developmental and evolutionary constraint on TP53 copy number, or perhaps evaded paying the cost of increased TP53 copy number altogether.
Hello. I am a published scientist and technical writer. I checked the journal article and your questions, and I can explain every thing to you, no problem.