Suljettu

Comparison of conventional noninvasive tests and natural anticoagulants in assessment of liver fibrosis stage.

Objectives:

Primary aim

To assess the performance of selected natural anticoagulants suing liver biopsy as the gold standard.

Secondary aim

Compare performance of natural anticoagulants with traditional noninvasive methods

We did study of Haemostatic Factors (ONLY) as Biomarkers of Significant Liver Fibrosis in Patients with Chronic Hepatitis C ( see below abstract) . We found it a negative study and challenged to be published. So we did reanalysis and included the results of fibroscn and other noninvasive score APRI, FIB-4 AND AST/ALT ratio and we want rewrite it after combining all these markers and score.

Importance: most of the studies in hematologic factors in liver disease did not assess liver fibrosis in large biopsy study….most studies for hematology assess this in cirrhotic ( but not patient with less degree of fibrosis)

What is needed:

To write the manuscript with new objective and including noninvasive scores and fibroscan in addition to the hemostatic factors

Rearrange and include tables

Update and included relevant references

Professional writing

---------

ABSTRACT

Background & Aims

Hemostatic factors are affected in chronic liver disease (CLD). Evidence regarding their use as noninvasive markers of CLD severity is scarce. We aimed to study the association between the levels of hemostatic factors and the severity of liver fibrosis in a large cohort of chronic HCV patients.

Methods

A cross sectional study was conducted on 402 adults with HCV. Liver biopsy and blood tests including platelet count, prothrombin time, international normalized ratio (INR), thrombin time (TT), antithrombin (AT), reptilase time (RT), fibrinogen, factor VII, protein C (PC), protein S(PS), free protein S, and C4 binding protein (C4BP) were performed. Variables significantly associated with significant (≥F2, Metavir) fibrosis on univariate analysis were included in a multivariate logistic regression model.

Results

Of the 402 eligible participants, 377 patients were included in the analysis. Significant fibrosis was present in 37.4%. INR increased while AT and PC decreased with increase in fibrosis stage (p value for all <0.001). C4BP levels reduction was associated with significant (≥F2) fibrosis (OR, 0.98; 95% CI: 0.97-0.99) adjusting for other parameters at multivariable analysis, so that as C4BP increases by one point, odds of having ≥F2 fibrosis decreases by 2%.

Conclusions

This study demonstrates a close relationship between hemostatic factors and histologic fibrosis progression in a large cohort of HCV patients. C4BP has the strongest association and could be used as a potential noninvasive marker of liver fibrosis. Further studies to validate this association are needed.

Taidot: Tutkimusten kirjoitus, Article Writing, haamukirjoittaminen, artikkelien uudelleenkirjoittaminen, Tutkimus

Näytä lisää: comparison shopping use, joomla price comparison, book price comparison, odds comparison webmasters, free price comparison post, product comparison site, natural health wellness graphic designs, create price comparison site, english mcq tests, price comparison script download, excel vba assessment tests, accounting assessment tests online, assessment tests agency, visual basic assessment tests, assessment language tests official lenguages, accounting assessment tests, online assessment tests for jobs, prove it assessment tests

Tietoa työnantajasta:
( 0 arvostelua ) Riyadh, Saudi Arabia

Projektin tunnus: #20802689

16 freelanceria on tarjonnut keskimäärin 1600$ tähän työhön

alibutt2014

Greetings! I am Ready to start this work, expect HIGH QUALITY from me. Looking Forward.......Thank you!

$1125 USD 14 päivässä
(827 arvostelua)
8.2
NoelReubenMuturi

Greetings, I am Noel, a PROFICIENT MEDICAL and ACADEMIC WRITER with a keen attention to detail. I am a TOP-RATED researcher with several years’ experience and over 10,000 completed research projects, including medical Lisää

$1500 USD 7 päivässä
(506 arvostelua)
7.9
uzmaq74

Hi, I have gone through the details and I can also write medical articles. Please check my portfolio/Cove letter I would be keen on working on your current project of comparing conventional non-invasive tests with n Lisää

$3000 USD 30 päivässä
(16 arvostelua)
5.4
kavitapatni3

Hi, I am a medical writer with a medical background having written hundreds of medical articles, blogs, and academic papers. I would be keen on working on your current project of comparing conventional non-invasive tes Lisää

$2000 USD 15 päivässä
(10 arvostelua)
5.0
PhDCoach

I believe I'm the perfect fit for your project; I am an American; completely comfortable with the requirements of this project and a medical writer with 10 years experience. Content creation for topics ranging from Hea Lisää

$5555 USD 30 päivässä
(11 arvostelua)
4.7
Fabiannn

Hi. I'm a researcher familiarized with medical writing and I have experience with developing/editing papers for submission. I can access peer-reviewed articles from Proquest and similar databases. You can propose inclu Lisää

$1100 USD 7 päivässä
(28 arvostelua)
5.0
roxanedunbar

I hold a 1st Class BSc in Biological Sciences, and am near completion of my PhD in Biomedical Sciences. I have also worked for the NHS as an audio typist and Medical Secretary for many years. From this experience, I ha Lisää

$750 USD 5 päivässä
(11 arvostelua)
4.0
jsubrina

I dont know how much impact factor journal you target; clinical study with cross sectional design; Your primary and secondary outcomes I understood well. if you add other factors in your re-written manuscript, it will Lisää

$1500 USD 14 päivässä
(7 arvostelua)
2.9
Mendeznatera

You can see my Google Academics profile at [login to view URL] and ResearchGate profile at [login to view URL] I will do all the tasks that you assign. I Lisää

$1250 USD 7 päivässä
(3 arvostelua)
2.9
Yaraessam1

Hello, I'm a student with alot of free time on her hands. I study biotechnology and the core of my studies is research and writing. I'm a very fast typist with 60+ words per minute and I'm familiar with microsoft word, Lisää

$750 USD 7 päivässä
(1 arvostelu)
0.4
$1250 USD 20 päivässä
(0 arvostelua)
0.0
coracoid

HI! You have already finished the paper and it just needs polishing and reformatting. Send me the full document and I'll see what I can do to help you in your presentation. I am a medical doctor and I have been doing t Lisää

$1450 USD 10 päivässä
(0 arvostelua)
0.0
$1250 USD 20 päivässä
(0 arvostelua)
0.0
nimrahshk94

Hey i have a medical background and i have been writing in medical field. Plz have a look on my samples provided Relevant Skills and Experience Research Technical writing Proposal writing Medical writing

$1250 USD 20 päivässä
(0 arvostelua)
0.0
kknkone

Time is a very important aspect here availability is also the factor, but delivering on time makes the customer happy which is what I will do deliver on time no matter what, I will dedicate all my time and hours to my Lisää

$1125 USD 7 päivässä
(0 arvostelua)
0.0
kozaktr

Hello there . If you need regular odds data , pre-match markets, live markets, live results and approved double checked results... And Live Video Streams..... Monthly payments ( details over chat ) I can provide you Lisää

$750 USD 1 päivässä
(0 arvostelua)
0.0